BMS 193885

Name: BMS 193885
Brand: TargetMol
SKU: T22608
Price: 760 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T22608Cas号 679839-66-8

别名 BMS193885

BMS 193885 是一种选择性和竞争性神经肽 Y(1) 受体拮抗剂，亲和力为 3.3 nM。

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产品编号 T22608 别名 BMS193885Cas号 679839-66-8

BMS 193885 是一种选择性和竞争性神经肽 Y(1) 受体拮抗剂，亲和力为 3.3 nM。

规格	价格	库存	数量
10 mg	¥ 5,880	35日内发货
50 mg	¥ 23,500	35日内发货

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产品介绍

生物活性

产品描述	BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM.
体外活性	BMS 193885 increases the Kd of [(125)I]PeptideYY from 0.35 nM to 0.65 nM without changing the Bmax (0.16 pmol/mg of protein) in SK-N-MC cells that endogenously express the neuropeptide Y(1) receptor[1]. BMS 193885 is a full antagonist with an apparent Kb of 4.5 nM measured by reversal of forskolin-stimulated inhibition of cAMP production by neuropeptide Y[1].
体内活性	BMS 193885 (10 mg/kg; i.p.) reduces one-hour neuropeptide Y-induced food intake in satiated rats, as well as spontaneous overnight food consumption. Chronic administration of BMS 193885 (10 mg/kg) i.p. for 44 days significantly reduces food intake and the rate of body weight gain compared to vehicle treated control without developing tolerance or affecting water intake[1].
别名	BMS193885

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: <13.62 mg/mL

DMSO: 63 mg/mL (92.5 mM)

溶液配制表